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Updated: Sep 11, 2025
09:21
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
12.1K
Advances in Ischemic Stroke Treatment: Current and Future Therapies
Benjamin W Y Lo1,2,3,4, Hitoshi Fukuda5
1Division of Neurosurgery, Queen Mary Hospital, Hong Kong Hospital Authority, Hong Kong, China. lo_benjamin@hotmail.com.
Neurology and Therapy
|August 12, 2025
Summary
This review covers stroke anatomy, pathophysiology, and treatments. Key findings show endovascular thrombectomy and medical therapy improve outcomes for anterior circulation strokes, even in extended time windows.
Area of Science:
- Neurology
- Vascular Medicine
- Neuroscience
Background:
- Understanding stroke anatomy, cerebral hypoperfusion, and collateral circulation is crucial for effective treatment.
- Recent advancements in stroke trials and therapies require evidence-based summarization.
Purpose of the Study:
- To provide an evidence-based update on stroke treatments and management principles.
- To review current concepts in stroke pathophysiology and anatomy.
- To explore emerging neurorehabilitation strategies.
Main Methods:
- Systematic review of stroke trials and treatments using PRISMA guidelines.
- Analysis of current literature on stroke anatomy, pathophysiology, and collateral circulation.
- Evaluation of neurorehabilitation interventions.
Main Results:
- Endovascular thrombectomy and medical therapy significantly improve functional independence at 90 days for anterior circulation strokes, including late windows up to 24 hours.
- Intensive systolic blood pressure control post-thrombectomy is linked to adverse outcomes.
- Emerging neurorehabilitation interventions like brain-computer interfaces and robotics show potential for maximizing neuroplasticity.
Conclusions:
- Current evidence supports the efficacy of endovascular thrombectomy and medical therapy for anterior circulation strokes within extended timeframes.
- Cautious blood pressure management is advised post-thrombectomy.
- Neurorehabilitation offers promising avenues for stroke recovery and improvement.
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