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Quantum Dot-Enabled Biosensing for Prostate Cancer Diagnostics.

Hossein Omidian¹, Erma J Gill¹, Luigi X Cubeddu¹

¹Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.

Nanomaterials (Basel, Switzerland)

|August 13, 2025

Summary

This summary is machine-generated.

Quantum dot (QD)-based biosensors show promise for advanced prostate cancer diagnostics, offering high sensitivity and specificity. Innovations are paving the way for low-cost, point-of-care screening and personalized treatment strategies.

Keywords:

biosensors multiplex diagnostics nanomaterials prostate-specific antigen (PSA)quantum dots

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Area of Science:

Nanotechnology
Biomedical Engineering
Analytical Chemistry

Background:

Prostate cancer diagnostics are evolving with new technologies.
Nanotechnology offers novel approaches for sensitive biomarker detection.
Quantum dots (QDs) are key nanomaterials in advanced biosensing.

Purpose of the Study:

To review quantum dot (QD)-based biosensors for prostate cancer biomarker detection.
To analyze sensing platforms, signal transduction, and performance metrics.
To highlight recent advances and future directions in QD diagnostics.

Main Methods:

Review of studies on QD-based biosensors for prostate cancer.
Analysis of QD composition, surface functionalization, and bio-interface engineering.
Assessment of detection limits, dynamic range, and sample compatibility (serum, urine, tissue).

Main Results:

QD-based biosensors demonstrate high sensitivity and specificity for prostate cancer biomarkers.
Green-synthesized QDs and smartphone-integrated platforms enable real-time, low-cost screening.
Multiplexed detection and tumor microenvironment monitoring are achievable at point-of-care.

Conclusions:

QD-based biosensors represent a significant advancement in prostate cancer diagnostics.
Further research is needed to overcome limitations and enable clinical translation.
Future directions include scalability and integration into routine clinical practice.