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Related Experiment Video

Updated: Jun 26, 2026

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Published on: December 9, 2022

Smart Hydrogels for Craniofacial Regeneration.

Hossein Omidian¹, Erma J Gill¹, Umadevi Kandalam²

¹Barry and Judy Silverman College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.

|June 25, 2026

Summary

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Hydrogel scaffolds are advanced platforms for craniofacial tissue regeneration, guiding cell behavior and tissue development. Optimized hydrogels show promise, but standardization is needed for clinical translation.

Area of Science:

Biomaterials Science
Regenerative Medicine
Craniofacial Biology

Background:

Hydrogel scaffolds are evolving from passive carriers to instructive microenvironments for craniofacial tissue regeneration.
They actively regulate cell fate, vascularization, immune responses, and tissue architecture.

Purpose of the Study:

To review hydrogel-associated strategies for diverse craniofacial tissues and cell types.
To analyze factors governing hydrogel performance in regeneration.
To identify challenges and future directions for clinical translation.

Main Methods:

Systematic review of hydrogel applications in dental pulp, periodontal ligament, gingival, bone, oral mucosa, and stem cell systems.
Analysis of scaffold composition, mechanics, signaling, and delivery methods.

Keywords:

craniofacial regeneration dental stem cells extracellular vesicles hydrogel scaffolds immunomodulatory biomaterials

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The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

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Last Updated: Jun 26, 2026

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Gelatin Methacryloyl Granular Hydrogel Scaffolds: High-throughput Microgel Fabrication, Lyophilization, Chemical Assembly, and 3D Bioprinting

Published on: December 9, 2022

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

The Synthesis of RGD-functionalized Hydrogels as a Tool for Therapeutic Applications

Published on: October 7, 2016

Evaluation of hydrogel interactions with biological components and the inflammatory niche.

Main Results:

Mineralized and ion-releasing hydrogels strongly supported osteogenesis and bone repair.
ECM-mimetic, peptide, collagen, fibrin, GelMA, alginate, HA, and chitosan hydrogels facilitated various soft and hard tissue reconstructions.
Responsive, antimicrobial, antioxidant, conductive, and immunomodulatory hydrogels target diseased microenvironments.

Conclusions:

Hydrogel performance depends on intricate interactions between biological sources, scaffold properties, and signaling mechanisms.
Significant preclinical data exists, but translation is hindered by formulation and validation heterogeneity.
Standardization, tissue-specific design, advanced models, and integrated assessments are crucial for future progress.