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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Updated: Sep 11, 2025

Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans
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Protein and Aging: Practicalities and Practice.

Stephanie Harris1, Jessica DePalma1, Hope Barkoukis1

  • 1Department of Nutrition, School of Medicine-WG 48, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA.

Nutrients
|August 14, 2025
PubMed
Summary
This summary is machine-generated.

Older adults need more dietary protein to maintain muscle and immune health. Recommendations range from 1.0-2.0 g/kg/day, with 25-30g per meal and pre-sleep protein also beneficial for muscle protein synthesis.

Keywords:
aginganimal and plant proteinchronic kidney diseasedietary proteinimmunosenescencemuscle protein synthesisolder adultspre-sleep protein feedsprotein intake distributionsarcopenia

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Area of Science:

  • Gerontology
  • Nutritional Science
  • Human Physiology

Background:

  • Dietary protein is crucial for muscle building, immune function, and wound healing.
  • Protein intake declines in older adults in the U.S. due to factors like reduced appetite and social isolation.
  • Aging is associated with decreased muscle protein synthesis and immunosenescence, increasing protein needs.

Purpose of the Study:

  • To highlight the increased protein requirements in aging populations.
  • To identify barriers to adequate protein consumption in older adults.
  • To recommend strategies for meeting elevated protein needs.

Main Methods:

  • This study is a literature review.
  • It synthesizes current research on protein requirements for older adults.
  • It examines factors influencing protein intake and utilization in aging.

Main Results:

  • Healthy aging individuals require at least 1.0-1.2 g/kg/day of dietary protein.
  • Those with chronic/acute conditions need 1.2-1.5 g/kg/day, potentially up to 2.0 g/kg/day for severe cases.
  • Distributing 25-30g of protein per meal and consuming 40g pre-sleep can optimize muscle protein synthesis (MPS).

Conclusions:

  • Adequate protein intake is vital for maintaining muscle strength, bone health, immune function, and quality of life in older adults.
  • Specific protein intake recommendations vary based on health status.
  • Strategic protein distribution and timing can enhance muscle health and amino acid utilization in the aging population.