Related Experiment Video
Updated: Sep 11, 2025

A New Technique for Quantitative Analysis of Hair Loss in Mice Using Grayscale Analysis
Published on: March 9, 2015
Pentacyclic Triterpenoid Maslinic Acid Promotes Hair Growth Comparable to Minoxidil: A New Insight on the Potential
Aprill Kee Oliva Mizushima1,2,3, Meryem Bouhoute3, Meriem Bejaoui3,4
1Tsukuba Life Science Innovation (T-LSI) Program, University of Tsukuba, Tsukuba City 305-8577, Japan.
Abstract:
Maslinic acid is a pentacyclic triterpene component of olive extracts. In this study, we elucidated the effects of maslinic acid on hair growth and explored its underlying mechanisms. The topical application of maslinic acid stimulates hair growth in mice comparable to minoxidil, where an acceleration in anagen induction was observed. Moreover, treatment with maslinic acid led to increased protein levels of CTNNB1 and VEGF, and upregulated the mRNA expression of trichogenic genes, including CTNNB1, ALPL, and FGF1. Additionally, crucial pathways and biological processes involved in hair growth were activated such the Wnt, Notch, MAPK, and angiogenesis. Interestingly, Iqcb1, a ciliogenesis-promoting gene, was found to be upregulated by maslinic acid, leading us to explore the potential link between hair growth and cilia activity. Notably, inhibiting cilia activity resulted in the downregulation of CTNNB1. Altogether, our study suggests that maslinic acid stimulates hair growth through the Wnt/β-catenin pathway and introduces a possible mechanism involving ciliary gene activity.
More Related Videos
10:09Rapid Genetic Analysis of Epithelial-Mesenchymal Signaling During Hair Regeneration
Published on: February 28, 2013
10:05Stimulation of Stem Cell Niches and Tissue Regeneration in Mouse Skin by Switchable Protoporphyrin IX-Dependent Photogeneration of Reactive Oxygen Species In Situ
Published on: May 8, 2020
Related Concept Videos
Accessory Structures of the Skin: Hair Growth and Types
Multipotency and Niche of Bulge Stem Cell
Accessory Structures of the Skin: Hair and Hair Follicles
Hair is a keratinous filament growing out of the epidermis. It is primarily made of dead, keratinized cells. Hair strands originate at the epidermal penetration called the hair follicle. The hair shaft is the part...
Antihypertensive Drugs: Vasodilators
Mechanism of Ciliary Motion
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
Abnormal Proliferation