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Related Concept Videos

Computed Tomography01:10

Computed Tomography

Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
Imaging Studies I: CT and MRI01:14

Imaging Studies I: CT and MRI

Introduction: MRI and CT scans are crucial advancements in medical imaging techniques, playing a vital role in diagnosing conditions related to the gastrointestinal (GI) system. Each scan serves distinct purposes, targets specific areas, and requires unique nursing duties.
Description of the Procedures
Computed Tomography (CT) scan:
Computed Tomography (CT) scans use X-ray technology to generate detailed images of bones, organs, and tissues. During the scan, the patient lies on a moving table...

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Building Up a High-throughput Screening Platform to Assess the Heterogeneity of HER2 Gene Amplification in Breast Cancers
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High-resolution microCT to assess breast microcalcification morphometry by histologic lesion subtype and radiologic

Sarah Schrup1, Santo Maimone2, Michael Villalba2

  • 1Mayo Clinic Graduate School of Biomedical Sciences, 200 1st St SW, Rochester, MN, 55902, USA. schrup.sarah@mayo.edu.

Breast Cancer Research and Treatment
|August 17, 2025
PubMed
Summary

Breast calcification shape and size, analyzed using microCT, differ between benign and malignant tissues. This 3D morphometry may aid in classifying calcifications to improve breast cancer diagnosis.

Keywords:
3DBreastMammographyMicroCTMicrocalcificationsMorphology

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Area of Science:

  • Biomedical Imaging
  • Radiology
  • Pathology

Background:

  • Breast calcifications are common mammographic findings.
  • Distinguishing benign from malignant calcifications is crucial for patient management.
  • Current methods for calcification analysis have limitations.

Purpose of the Study:

  • To assess associations of 3D morphometry of breast calcifications with underlying histopathology.
  • To evaluate the potential for classifying tissue calcifications to optimize identification and diagnosis of severe breast pathology.

Main Methods:

  • Compared morphometry of 12,216 calcifications in 156 breast tissue blocks (benign, ductal carcinoma in situ, invasive carcinoma) using microCT.
  • Analyzed 3D reconstructions of calcifications and compared morphometry to pathologic diagnosis.
  • Radiologists assessed biopsy need and calcification morphology from microCT images.

Main Results:

  • Breast cancer-associated calcifications were significantly larger and more cylindrical than benign ones.
  • Calcification volume positively associated with ductal carcinoma in situ grade.
  • Radiologists achieved 92% agreement on biopsy recommendations with moderate sensitivity and specificity.

Conclusions:

  • Tissue calcification morphometry varies by lesion type, supporting potential for classification.
  • Future studies may develop a pathologic classification linked to diagnosis and mammographic findings.
  • 3D microCT analysis offers a novel approach to characterizing breast calcifications.