Three new polyketones from mangrove endophytic fungus aspergillus sp. HMGh1-1 and their insecticidal activity

A new phenylacetic acid, methoxy-graphislactones C (1), a new anthraquinone (1'E)-6,8-di-O-methyl averanti (2), a new phenanthrene derivative, 12-methyl entonaemin A (3) and five previously reported compounds (4-8) were isolated from the fermented extracts of the mangrove endophytic fungus Aspergillus sp. HMGh1-1. The structures and absolute configurations of the new compounds were determined by spectroscopic techniques (high-resolution mass spectrometry, NMR), ECD calculations, and single-crystal X-ray analysis. Compounds 1-8 were screened for insecticidal activity against Diaphorina citri Kuwayama, and compound 3 exhibited significant insecticidal activity, with a corrected efficacy of 90.97 %.