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Related Experiment Video

Updated: Sep 11, 2025

Autonomic Function Following Concussion in Youth Athletes: An Exploration of Heart Rate Variability Using 24-hour Recording Methodology
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Early Cardiac Dysfunction in Adolescents With Low Vigorous Physical Activity.

Samuel J Burden1,2, Najmeh Zare1, Oliver J Rider3

  • 1Department of Paediatrics University of Oxford, John Radcliffe Hospital Oxford UK.

Journal of the American Heart Association
|August 18, 2025
PubMed
Summary
This summary is machine-generated.

Low vigorous physical activity (VPA) in adolescents is linked to adverse left ventricular diastolic function (LVDF), independent of adiposity. This diastolic dysfunction predicts lower cardiorespiratory fitness, highlighting VPA

Keywords:
cardiac functionexerciseobesityphysical activityprevention

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Area of Science:

  • Cardiology
  • Pediatric Health
  • Exercise Physiology

Background:

  • Adverse left ventricular diastolic function (LVDF) is an early indicator of cardiac dysfunction, worsening with age and potentially leading to heart failure.
  • The onset of LVDF deterioration and the influence of physical activity (PA) in adolescents remain unclear.
  • This study investigated the relationship between LVDF and PA intensity in adolescents, considering adiposity and cardiorespiratory fitness.

Purpose of the Study:

  • To assess the independent associations of adverse LVDF with varying levels of physical activity (PA) in adolescents.
  • To compare the impact of PA on LVDF with the influence of adiposity.
  • To examine the effect of adverse LVDF resulting from low PA on cardiorespiratory fitness.

Main Methods:

  • 127 adolescents (11-18 years) underwent echocardiography for LVDF assessment.
  • 7-day PA was measured using accelerometry; adiposity was quantified by BMI Z-scores.
  • Adverse LVDF was defined by a Z-score <-2 for BSA-adjusted septal early diastolic tissue peak velocity.

Main Results:

  • Adverse LVDF was prevalent in adolescents with overweight (28%) and obesity (45%), particularly those with low vigorous PA (VPA).
  • Increased VPA significantly reduced the odds of adverse LVDF, independently of adiposity.
  • Low VPA (5 min/day) was causally linked to 2.4 mL/kg/min lower peak oxygen consumption due to adverse LVDF compared to 15 min/day.

Conclusions:

  • Low VPA in adolescence is independently associated with adverse LVDF, irrespective of adiposity.
  • Impaired LVDF in adolescents predicts reduced cardiorespiratory fitness.
  • Vigorous physical activity is crucial for maintaining healthy LVDF in young individuals.