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Jiao-Tai-Wan Improves Cognitive Impairment by Regulating Nrf2/ARE/HO-1 Signaling Pathway in APP/PS1 Mice
Xin-Chen Wang1,2, Guang-Liang Wu3,4, Hai-Yan Cai5
1Department of Pharmaceutical Engineering, College of Food and Pharmaceutical Engineering, Zhaoqing University, Zhaoqing, China.
Neurochemical Research
|August 18, 2025
Summary
Jiao Tai Wan (JTW), a traditional Chinese medicine, improves cognitive function in Alzheimer
Area of Science:
- Neuroscience
- Pharmacology
- Traditional Chinese Medicine
Background:
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder impacting memory, intelligence, and behavior.
- Jiao Tai Wan (JTW), a formula of Coptis chinensis and Cinnamon (10:1 ratio), is known to promote cognitive function.
- The precise mechanisms underlying JTW's cognitive benefits require systematic investigation.
Purpose of the Study:
- To investigate the therapeutic effects and underlying mechanisms of Jiao Tai Wan (JTW) on cognitive deficits in a mouse model of Alzheimer's disease (APP/PS1 mice).
- To evaluate JTW's impact on neurodegeneration, amyloidosis, cholinergic system, inflammation, oxidative stress, and the Nrf2/ARE/HO-1 pathway.
Main Methods:
- Behavioral tests (Morris water maze, Y-maze) assessed cognitive and spatial learning abilities.
- Molecular techniques including PCR, ELISA, Nissl staining, and Western blotting were employed.
- Analysis included neurotrophic factors (BDNF, NGF), synaptic proteins (SYP), amyloid-beta (Aβ) levels, secretase activities, cholinergic markers (Ach, AchE, ChAT), inflammatory factors, oxidative stress indicators, and the Nrf2/ARE/HO-1 pathway.
Main Results:
- JTW significantly improved learning, memory, and spatial exploration in APP/PS1 mice.
- JTW treatment ameliorated neurodegenerative lesions, reduced cerebral amyloidosis, and enhanced the cholinergic nervous system.
- JTW inhibited inflammatory factors and oxidative stress, and notably regulated the Nrf2/ARE/HO-1 pathway.
Conclusions:
- Jiao Tai Wan (JTW) demonstrates significant neuroprotective effects against Alzheimer's disease pathology in a mouse model.
- JTW enhances cognitive function by modulating the Nrf2/ARE/HO-1 pathway, increasing neurotrophic factors, and reducing neuroinflammation and oxidative stress.
- These findings support JTW as a potential therapeutic agent for Alzheimer's disease, warranting further clinical investigation.
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