Related Experiment Video
Updated: Sep 11, 2025
08:02
A Mouse Ear Model for Allergic Contact Dermatitis Evaluation
Published on: March 24, 2023
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The Changing Spectrum of Pediatric Allergic Contact Dermatitis: A Prospective Multicentric Study in Spain
Nidia Planella-Fontanillas1,2, David Pesqué1,3, Leopoldo Borrego4
1From the, Department of Dermatology, Hospital del Mar Research Institute, Barcelona, Spain.
Dermatitis : Contact, Atopic, Occupational, Drug
|August 18, 2025
Summary
Allergic contact dermatitis (ACD) affects children, with patch testing revealing high sensitization rates. Emerging allergens like linalool and limonene hydroperoxides require attention for better pediatric ACD management.
Area of Science:
- Dermatology
- Pediatrics
- Allergology
Background:
- Allergic contact dermatitis (ACD) prevalence is rising in children, showing age-related differences.
- Understanding these patterns is crucial for effective diagnosis and management.
- Pediatric ACD requires updated clinical and epidemiological data.
Purpose of the Study:
- To update clinical and epidemiological characteristics of pediatric ACD.
- To determine sensitization frequencies and the relevance of positive patch tests.
- To analyze age-specific variations in pediatric ACD.
Main Methods:
- Prospective multicenter study of pediatric patients (0-16 years) using the REIDAC registry.
- Stratification into two age groups: 0-5 years and 6-16 years.
- Patch testing conducted with GEIDAC baseline and extended series (Jan 2019 - Dec 2023).
Main Results:
- 508 children underwent patch testing; 179 (35.2%) were sensitized.
- In 0-5 years group (n=41), 24.4% sensitized; face and hands most affected. Linalool and limonene hydroperoxides were top allergens.
- In 6-16 years group (n=467), 36.2% sensitized; face and hands most affected. Linalool hydroperoxide and methylisothiazolinone were top allergens.
Conclusions:
- High sensitization rates in both pediatric age groups underscore the importance of patch testing.
- Linalool and limonene hydroperoxides are identified as significant emerging sensitizers.
- Age-specific management strategies are essential for improving pediatric ACD outcomes.
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