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Bias-Modulated Dual-Channel Photoelectrochemical Immunosensor Enabled by a Dual-Responsive Nanolabel.
Yujia Dong1, Yong Hao1, Haiyang Li1
1Key Laboratory of Interfacial Reaction & Sensing Analysis in Universities of Shandong, School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, P. R. China.
Analytical Chemistry
|August 19, 2025
Summary
This study introduces a novel dual-channel photoelectrochemical (PEC) immunosensor for detecting breast cancer biomarker CA15-3. This advanced sensor design minimizes false positives and enhances accuracy in complex biological samples.
Area of Science:
- Electrochemistry
- Biomarker Detection
- Nanomaterials
Background:
- Photoelectrochemical (PEC) immunosensors offer high sensitivity for biomarker detection.
- Conventional PEC sensors face challenges with false positives in complex biological samples due to non-specific binding.
- Dual-channel designs can improve accuracy through signal verification and complementation.
Purpose of the Study:
- To develop a novel bias-modulated dual-channel PEC immunosensor for efficient detection of the breast cancer biomarker CA15-3.
- To address the limitations of conventional PEC sensors in complex biological matrices.
- To enhance both the sensitivity and accuracy of biomarker detection.
Main Methods:
- Fabrication of a dual-channel PEC immunosensor using In4SnS8/Bi2O2S and BiOBr0.8I0.2 photoactive materials on an ITO electrode.
- Independent acquisition of anode and cathode PEC signals via bias modulation.
- Utilizing ZnFe2O4 as a dual-responsive nanolabel to modulate anode and cathode signals upon immunorecognition.
Main Results:
- The dual-channel design effectively reduced false-positive results by utilizing mutual signal verification.
- The bias-modulated approach allowed for independent control and acquisition of anode and cathode signals.
- The ZnFe2O4 nanolabel demonstrated a dual-responsive behavior, enhancing one signal while reducing the other, leading to improved detection.
- Integration of the two independent signals significantly enhanced both the sensitivity and accuracy of CA15-3 detection.
Conclusions:
- A novel bias-modulated dual-channel PEC immunosensor was successfully developed for sensitive and accurate CA15-3 detection.
- This sensor design offers a promising strategy to overcome the limitations of non-specific binding in complex biological samples.
- The developed immunosensor holds significant potential for early breast cancer screening and clinical diagnostic applications.
