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Updated: Sep 10, 2025

A Nonviral Approach to Generate Transient Chimeric Antigen Receptor T Cells Using mRNA for Cancer Immunotherapy
Published on: February 21, 2025
Systemic mRNA aggregates elicit immunologic reprogramming that unlocks anti-cancer immunity
Hector R Mendez-Gomez1, John A Ligon2, Ashley P Ghiaseddin1
1Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, FL, USA.
None:
Successful cancer immunotherapy requires novel approaches that overcome intratumoral immunosuppression and peripheral tolerance. In a recent manuscript describing intravenously administered mRNA-loaded lipid particle aggregates (RNA-LPAs), we demonstrate the ability to reprogram both the tumor microenvironment and periphery enabling cancer-specific immunity simultaneously generated to compete against immunologically 'cold' malignancies like glioblastoma.
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