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Towards the elimination of infectious HPV: exploiting CRISPR/Cas innovations

Wei Liu1, Yingyan Jiang2, Cheng Wang3

  • 1College of Laboratory Medicine, Jilin Medical University, Jilin, China.

Frontiers in Cellular and Infection Microbiology
|August 20, 2025
PubMed

Insights

Human Papillomavirus (HPV) infections can lead to cancer. The CRISPR/Cas system offers a promising new gene-editing therapy to target and eliminate the HPV genome, potentially revolutionizing treatment.

Area of Science:

  • Molecular Biology
  • Oncology
  • Virology
  • Gene Therapy

Background:

  • Human Papillomavirus (HPV) is linked to numerous human cancers.
  • Current HPV treatments often face drug resistance and adverse effects.
  • Novel therapeutic strategies are crucial for managing HPV-induced diseases.

Purpose of the Study:

  • To review the potential of the CRISPR/Cas system for treating HPV infections.
  • To explore the application of CRISPR/Cas technology in combating HPV-related malignancies.
  • To discuss the prospective efficacy, opportunities, and challenges of CRISPR/Cas for HPV.

Main Methods:

  • Review of existing literature on CRISPR/Cas gene-editing technology.
  • Analysis of CRISPR/Cas system's mechanism for targeting viral genomes.
  • Evaluation of CRISPR/Cas applications in the context of HPV infections and associated cancers.

Main Results:

  • CRISPR/Cas system demonstrates significant potential for selective targeting and elimination of viral genomes.
  • This gene-editing approach shows promise in overcoming limitations of current non-virus-specific therapies.
  • CRISPR/Cas offers a novel strategy for the management of HPV infections and prevention of HPV-induced cancers.

Conclusions:

  • The CRISPR/Cas system represents a groundbreaking and promising therapeutic approach for HPV infections.
  • Further research and development are needed to address challenges and optimize CRISPR/Cas for clinical application.
  • CRISPR/Cas technology holds potential as a future cure for HPV and related cancers.
Keywords:
CRISPR/CasHPVHPV-associated diseasesgene editingviral genome targeting therapy

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