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Linezolid-Induced Glossitis and Papillitis in Orthopedic Patients With Postoperative Infection: A Case Report
Ryan J Blake1, Benjamin M Frye1,2, Allison M Lastinger1,2,3
1Department of Orthopaedic Surgery, West Virginia University, Morgantown, West Virginia, USA.
Case Reports in Infectious Diseases
|August 20, 2025
Summary
Linezolid antibiotic therapy can cause unusual oral side effects like tongue swelling and pain, even with short-term use. This study highlights atypical reactions beyond the typical black hairy tongue presentation.
Area of Science:
- Infectious Diseases
- Pharmacology
- Oral Medicine
Background:
- Linezolid is an oxazolidinone antibiotic effective against Gram-positive bacterial infections.
- Commonly prescribed for skin, bone, and soft tissue infections.
- Known adverse effects include hematologic and neurologic toxicities.
Observation:
- Three orthopedic patients developed oral pain and circumvallate papillae swelling after 10-day linezolid courses.
- Symptoms occurred without the characteristic discoloration of black hairy tongue.
- Patients had superficial infections and no signs of drug toxicity or neutropenia.
Findings:
- Atypical oral side effects, including glossitis and papillitis, emerged with short-term linezolid use.
- These reactions differed from previously reported cases associated with long-term therapy.
- Absence of coinfections or other medications suggests a direct correlation with linezolid.
Implications:
- Highlights the need for vigilance regarding unusual oral symptoms during short-term linezolid treatment.
- Expands the known side-effect profile of linezolid, including atypical oral manifestations.
- Suggests further research into the mechanisms of linezolid-induced oral adverse effects is warranted.
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