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Related Concept Videos

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Related Experiment Video

Updated: Sep 10, 2025

Author Spotlight: Innovative Microneedle-Based Strategies for Enhanced Exosome Delivery and Stability
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ROS-Scavenging Multifunctional Microneedle Patch Facilitating Wound Healing.

Mahshid Kharaziha1,2, Sahar Salehi2, Mahshid Shokri1

  • 1Department of Materials Engineering, Isfahan University of Technology, Isfahan, 84156-83111, Iran.

Advanced Healthcare Materials
|August 20, 2025
PubMed
Summary

This study developed a microneedle array that reduces inflammation and scarring in chronic wounds. The novel dressing promotes healing by scavenging reactive oxygen species (ROS) and modulating the immune response.

Keywords:
ROS scavengingarginine functionalized particlesflightless I siRNAimmunomodulatory propertiesmicroneedle patchwound healing

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Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Wound Healing Research

Background:

  • Chronic wounds exhibit delayed healing due to inflammation, fibrosis, and excessive reactive oxygen species (ROS).
  • Dysfunctional wound microenvironments impede tissue repair and promote scarring.
  • Current treatments often fail to address the complex interplay of factors hindering chronic wound resolution.

Purpose of the Study:

  • To develop a multifunctional microneedle array (MNA) for chronic wound management.
  • To combine reactive oxygen species (ROS) scavenging with accelerated tissue formation.
  • To investigate the immunomodulatory effects of the MNA on wound healing.

Main Methods:

  • Fabrication of a hyaluronic acid methacrylate (HaMA) microneedle array.
  • Loading the array with Flightless I (Flii) siRNA-loaded arginine-functionalized poly (β-amino ester)-alginate (APA) particles.
  • In vitro studies using HaCaT cells and in vivo studies using a rat chronic wound model.

Main Results:

  • The siRNA-APA-loaded MNA demonstrated enhanced ROS scavenging via nitric oxide (NO) delivery.
  • Silencing Flii expression and reducing pro-inflammatory cytokines (TNF-α, IL6) were observed.
  • Transdermal application of the MNA in rats mitigated scar formation and promoted wound healing by reducing inflammation.

Conclusions:

  • The developed siRNA-APA-laden HaMA MNA possesses ROS scavenging and immunomodulatory properties.
  • This MNA shows significant potential for effective chronic wound management.
  • The findings offer promising insights for advanced wound dressing applications.