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Skeletal editing based on nitrogen-atom manipulation.

Linlin Ding1, Yang Fan1, Hongjian Lu1,2

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Nitrogen-atom editing (N-atom editing) advances synthetic chemistry by enabling new molecular transformations. This review covers recent breakthroughs and applications in medicinal chemistry and materials science.

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Area of Science:

  • Synthetic Chemistry
  • Organic Chemistry
  • Medicinal Chemistry

Background:

  • Nitrogen atoms are crucial in bioactive molecules and synthetic building blocks.
  • Nitrogen-atom editing (N-atom editing) has gained prominence due to its utility.
  • Recent advancements have expanded N-atom editing's scope and applications.

Purpose of the Study:

  • To provide a comprehensive overview of N-atom editing methodologies.
  • To discuss mechanistic insights and historical development.
  • To highlight applications in synthesizing bioactive molecules and materials.

Main Methods:

  • Review of recent literature on N-atom editing techniques.
  • Detailed discussion of mechanistic pathways.
  • Analysis of applications in medicinal chemistry and materials science.

Main Results:

  • Substantial progress in novel N-atom editing methodologies over the past five years.
  • Demonstration of N-atom editing's transformative potential in various fields.
  • Illustrative examples of synthesizing and modifying complex molecules.

Conclusions:

  • N-atom editing is a powerful tool with expanding applications.
  • Mechanistic understanding provides conceptual tools for future research.
  • Future perspectives and challenges in N-atom editing are outlined.