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Exploring thyroid eye disease in Brazil: insights from a single-center study
Danilo Villagelin1, Nicolas Perini2, Roberto Bernardo Santos3
1Pontifícia Universidade Católica de Campinas Escola de Ciências da Vida Faculdade de Medicina Campinas SP Brasil Pontifícia Universidade Católica de Campinas, Escola de Ciências da Vida, Faculdade de Medicina, Campinas, SP, Brasil.
Archives of Endocrinology and Metabolism
|August 20, 2025
Summary
Graves' disease patients in Brazil show a 51% prevalence of thyroid eye disease (TED). Older age, smoking, and goiter size correlate with TED severity, informing cost analyses for new treatments.
Area of Science:
- Endocrinology
- Ophthalmology
Background:
- Graves' disease (GD) is the primary cause of hyperthyroidism worldwide.
- Thyroid eye disease (TED) affects 40% of GD patients, necessitating updated prevalence data for treatment cost analysis.
Purpose of the Study:
- To determine the prevalence of TED in a Brazilian GD patient cohort.
- To provide data for economic evaluations of emerging TED therapies.
Main Methods:
- Retrospective analysis of 660 GD patients diagnosed between 1999 and 2019.
- Classification of patients based on TED presence and severity.
Main Results:
- Overall TED prevalence was 51% (mild 33%, moderate-to-severe 16%, sight-threatening 1%).
- Older age at diagnosis, smoking, and goiter size were significantly associated with TED presence and severity.
Conclusions:
- This study establishes TED prevalence in Brazil, crucial for cost-effectiveness research.
- Findings support healthcare planning for managing TED and implementing new treatments.
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