Dual-site beta transcranial alternating current stimulation during a bimanual coordination task modulates functional
Mareike A Gann1, Ilenia Paparella2, Catharina Zich3
1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Dual-site transcranial alternating current stimulation (tACS) modulated brain connectivity but did not significantly alter behavior in a bimanual coordination task. Future research should explore inhibitory mechanisms to confirm causal links.
Area of Science:
- Neuroscience
- Cognitive Science
- Brain Stimulation
Background:
- Brain network communication relies on functional connectivity.
- Dual-site transcranial alternating current stimulation (tACS) is a non-invasive method to modulate cortical connectivity.
Purpose of the Study:
- To modulate inter-regional functional connectivity using dual-site tACS on bilateral primary motor cortices (M1s).
- To investigate the impact of this modulation on behavior during bimanual coordination tasks.
Main Methods:
- Functional magnetic resonance imaging (fMRI) recorded brain activity during a bimanual coordination task.
- Participants received sham, zero-phase, or jittered-phase beta (20 Hz) tACS over bilateral M1s in a within-subjects design.
Main Results:
- Zero-phase tACS attenuated interhemispheric connectivity.
- Active tACS types differentially affected M1 connectivity with premotor and supplementary motor areas.
- Individual E-field strength correlated with functional connectivity in the zero-phase condition.
Conclusions:
- Dual-site beta tACS over M1s altered motor area functional connectivity.
- Observed effects did not translate to significant behavioral changes, potentially due to sample size limitations.
- Future studies should incorporate measures like interhemispheric inhibition to strengthen causal interpretations.
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