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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment
Published on: May 25, 2017
Advances in the Medical Treatment of Clostridioides difficile Infection
Nirja Mehta1, Colleen Kraft2, Stuart Johnson3
1Division of Infectious Diseases, Department of Medicine, Emory University Midtown, 550 Peachtree Avenue NE, Medical Office Tower 7th Floor, Atlanta, GA 30308, USA.
Abstract:
Clostridioides difficile medical management has changed significantly over the past decade with emphasis on preventing recurrent infection. This review compares current guidelines on the treatment of initial, recurrent, fulminant, and pediatric C difficile infection (CDI) and evaluates the mechanisms and clinical use of available antibiotics for CDI. C difficile has complex resistance mechanisms to vancomycin, fidaxomicin, and metronidazole which may play a role in treatment outcomes. Antibiotics such as tigecycline and rifaximin as well as monoclonal antibodies against toxin B may play a role in adjunctive therapy. Additional therapies under development include new narrow therapeutic antibiotics.
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