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Updated: Sep 10, 2025
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Drimane sesquiterpenoids from cultures of the basidiomycete Panellus pusillus
Prapairat Seephonkai1, Rachada Chanphen2, Patchanee Auncharoen2
1Department of Chemistry and Center of Excellence for Innovation in Chemistry (PERCH-CIC), Faculty of Science, Mahasarakham University, Khamriang, Kantarawichai, Maha Sarakham 44150, Thailand.
Abstract:
In the quest for novel compounds with potent activities against human infectious diseases from fungi in Thailand, cultures of the basidiomycete Panellus pusillus strain TBRC-BCC 43793 were chemically investigated. A new drimane sesquiterpenoid, 1β-hydroxypereniporin A (1), together with a known drimane, 6β-hydroxy-isodrimenin, was isolated using silica gel column chromatography and preparative High Performance Liquid Chromatography (HPLC). Its structure was elucidated on the basis of the spectroscopic method. The isolated compounds were inactive in the antiplasmodial, antimycobacterial, and antibacterial activity assays.
