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Positron Emission Tomography

Positron Emission Tomography

Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...

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Related Experiment Video

Updated: Sep 10, 2025

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent

Published on: September 3, 2013

Dedicated prostate DOI-TOF-PET based on the ProVision detection concept.

Hong Phuc Vo¹, Themistoklis Williams², Katayoun Doroud²

¹Institute of Medical Engineering, University of Lübeck, Lübeck, Germany.

Physics in Medicine and Biology

|August 22, 2025

Summary

This summary is machine-generated.

The ProVision scanner shows promise for prostate PET imaging with its novel detector technology. However, limited angular coverage causes image distortions, despite advanced reconstruction techniques.

Keywords:

PET dedicated PET prostate PET

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Area of Science:

Medical Imaging
Nuclear Medicine
Positron Emission Tomography (PET)

Background:

The ProVision scanner is a dedicated prostate PET system utilizing advanced detector technology with depth-of-interaction (DOI) and time-of-flight (TOF) capabilities.
Limited angular coverage is a characteristic of the ProVision scanner, potentially impacting image reconstruction and quality.

Purpose of the Study:

To develop a flexible image reconstruction framework for the ProVision scanner.
To evaluate the image performance and identify limitations of the current ProVision scanners.

Main Methods:

Utilized experimental datasets including point sources and phantoms (image quality, pelvic).
Employed a multi-offset scanning protocol to address oblique lines of response and data truncation.
Applied list-mode Maximum Likelihood Expectation Maximisation (MLEM) with TOF information for image reconstruction.
Incorporated system matrix and sensitivity models accounting for detector attenuation and position uncertainty.

Main Results:

The ProVision scanner demonstrated good spatial resolution in the coronal plane.
Image distortions, specifically elongations, were observed due to limited angular coverage.
Time-of-flight (TOF) and depth-of-interaction (DOI) information, along with multi-offset scanning, did not fully correct these distortions.

Conclusions:

The ProVision scanner concept offers potential for fast, cost-effective PET imaging without CT, owing to its innovative detector technology.
Current limitations include image distortions caused by restricted angular coverage.
Future advancements in timing resolution, regularization, and artificial intelligence are anticipated to mitigate artifacts and improve image quality.