Unraveling the antagonistic roles of helper NLRs in plant immunity
Yao Gong1, Zhengjia Wang2, Liangsheng Zhang3
1Zhejiang Key Laboratory of Horticultural Crop Quality Improvement, College of Agriculture and Biotechnology, Zhejiang University, Hangzhou, China.
Abstract:
Two recent studies (Huang et al. and Xiao et al.) reveal how EDS1-SAG101 facilitates NRG1A resistosome formation, triggering immunity. They also show truncated NRG1C as a negative regulator that sequesters EDS1-SAG101, preventing overactivation. These breakthroughs highlight evolutionarily conserved plant defense mechanisms with implications for engineering resilient crops.
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