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Updated: Sep 10, 2025

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
Alterations of the skin microbiome in multiple system atrophy: a pilot study
Daji Chen1, Lang Sun2, Linlin Wan1,3,4,5,6
1Department of Neurology, Xiangya Hospital, Central South University, Changsha, 410008, China.
None:
Multiple system atrophy (MSA) alters skin physiology, potentially impacting skin microbiota. This pilot study investigated whether skin microbiota differs in MSA and whether these differences relate to disease severity. Using 16S rRNA sequencing of cervical and axillary sites in MSA, Parkinson's disease, and controls, we identified distinct microbial patterns among groups. These patterns allowed cohort classification and showed strong associations with clinical symptoms, suggesting disease-related microbial alterations in MSA.
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