Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NMR Spectrometers: Overview01:20

NMR Spectrometers: Overview

1.3K
NMR spectrometers consist of a strong magnet, a radiofrequency transmitter, and a detector attached to a computer console for recording spectra of samples containing NMR-active nuclei. In first-generation NMR instruments called continuous-wave spectrometers, the resonance frequencies of the nuclei are determined by frequency-sweep or field-sweep methods. The magnetic field strength is fixed and the rf signal is swept in the former, while the radiofrequency signal is fixed and the magnetic field...
1.3K
NMR Spectrometers: Resolution and Error Correction01:14

NMR Spectrometers: Resolution and Error Correction

774
When magnetic nuclei in a sample achieve resonance and undergo relaxation, the signal detected in NMR is an approximately exponential free induction decay. Fourier transform of an exponential decay yields a Lorentzian peak in the frequency domain. Lorentzian peaks in an NMR spectrum are defined by their amplitude, full width at half maximum, and position, where the peak width is governed by the spin-spin relaxation time alone. In real experiments, however, the applied magnetic field is rendered...
774
NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences01:17

NMR Spectrometers: Radiofrequency Pulses and Pulse Sequences

915
A pulse is a short burst of radio waves distributed over a range of frequencies that simultaneously excites all the nuclei in the sample. Upon passing a radio frequency pulse along the x-axis, the nuclei absorb energy corresponding to their Larmor frequencies and achieve resonance. This shifts the net magnetization vector from the z-axis toward the transverse plane. This angle of rotation of the magnetization vector, or the flip angle, is proportional to the duration and intensity of the pulse.
915
Double Resonance Techniques: Overview01:12

Double Resonance Techniques: Overview

291
Double resonance techniques in Nuclear Magnetic Resonance (NMR) spectroscopy involve the simultaneous application of two different frequencies or radiofrequency pulses to manipulate and observe two distinct nuclear spins. One important application of double resonance is spin decoupling, which selectively suppresses coupling with one type of nucleus while observing the NMR signal from another nucleus, simplifying the spectrum and enhancing resolution.
Spin decoupling is usually achieved by...
291
Mass Analyzers: Common Types01:19

Mass Analyzers: Common Types

705
The quadrupole mass analyzer consists of four cylindrical metal rods arranged in a diamond carrying a DC voltage and a radio-frequency AC voltage. The motion of ions through the quadrupole depends on the field strength, causing only ions of a certain m/z to resonate successfully and strike the detector at a given field strength. Though the transmission rate for these analyzers is high, the exact elemental composition of the sample is not determined because of low resolution; however, they are...
705
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

530
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
530

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

When life changes everything: a GP's return to work after bereavement.

The British journal of general practice : the journal of the Royal College of General Practitioners·2026
Same author

Breakdown of Disorder-Suppressed Floquet Heating under Two-Frequency Driving.

Physical review letters·2026
Same author

Nanodiamond Sensing of the Transmetalation Kinetics of Gd-DTPA in Individual Levitated Microdroplets.

The journal of physical chemistry. B·2026
Same author

Sensing with discrete time crystals.

Nature physics·2026
Same author

Out-of-time-order correlators bridge classical transport and quantum dynamics.

The Journal of chemical physics·2026
Same author

The lived experience of persons who attempt suicide: a bottom-up review co-designed, co-produced and co-written by experts by experience and academics.

World psychiatry : official journal of the World Psychiatric Association (WPA)·2026
Same journal

Localization-driven exchange contrast in diffusion exchange spectroscopy.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

4.5 Tesla superconducting miniature magnet in liquid nitrogen.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Folding and unfolding dynamics of a DNA aptamer studied by heteronuclear <sup>1</sup>H-<sup>13</sup>C correlation zz-exchange spectroscopy.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Multi-spin control from one-spin pulses.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Altering MRI rotating frame relaxations by changing the truncation level of Hyperbolic Secant pulse.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
Same journal

Effects of proton exchange on the lifetimes of long-lived states in aliphatic chains.

Journal of magnetic resonance (San Diego, Calif. : 1997)·2026
See all related articles

Related Experiment Video

Updated: Sep 10, 2025

Hyperpolarized Xenon for NMR and MRI Applications
16:20

Hyperpolarized Xenon for NMR and MRI Applications

Published on: September 6, 2012

19.7K

High-speed, high-memory NMR spectrometer and hyperpolarizer.

Leo Joon Il Moon1, William Beatrez2, Jason Ball3

  • 1Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Chemical Science Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Journal of Magnetic Resonance (San Diego, Calif. : 1997)
|August 24, 2025
PubMed
Summary
This summary is machine-generated.

A new nuclear magnetic resonance (NMR) spectrometer uses a high-speed arbitrary waveform transceiver (AWT) for advanced electron-nuclear spin control and dynamic nuclear polarization (DNP). This enables improved signal-to-noise ratios and opens new possibilities in quantum sensing.

Keywords:
Arbitrary waveform transceiverDynamics nuclear polarizationElectron-nuclear spin controlInterpolation and decimationPhase-sensitive detectionPulse sequence programmingQuantum sensing

More Related Videos

Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate
11:57

Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

Published on: September 13, 2019

6.7K
Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
11:43

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

10.6K

Related Experiment Videos

Last Updated: Sep 10, 2025

Hyperpolarized Xenon for NMR and MRI Applications
16:20

Hyperpolarized Xenon for NMR and MRI Applications

Published on: September 6, 2012

19.7K
Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate
11:57

Measuring the Spin-Lattice Relaxation Magnetic Field Dependence of Hyperpolarized [1-13C]pyruvate

Published on: September 13, 2019

6.7K
Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging
11:43

Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy and Imaging

Published on: December 30, 2016

10.6K

Area of Science:

  • Spectroscopy
  • Quantum Sensing
  • Materials Science

Background:

  • Nuclear Magnetic Resonance (NMR) spectroscopy is a powerful tool for analyzing molecular structure and dynamics.
  • Dynamic Nuclear Polarization (DNP) enhances NMR sensitivity by transferring polarization from electron spins to nuclear spins.
  • Current NMR systems face limitations in pulse control speed and signal processing, hindering advanced applications.

Purpose of the Study:

  • To develop a novel NMR spectrometer with integrated electron-nuclear spin control and DNP capabilities.
  • To leverage a high-speed arbitrary waveform transceiver (AWT) for enhanced NMR performance.
  • To explore new avenues for NMR pulse control, DNP, and quantum sensing applications.

Main Methods:

  • Incorporation of a high-speed arbitrary waveform transceiver (AWT) - Tabor Proteus P9484M.
  • Optimization for integrated electron-nuclear spin control and dynamic nuclear polarization (DNP).
  • Utilizing rapid sampling rates (9 Gs/s), large memory (16 GB), and high data transfer (6 Gs/s) for NMR operations.

Main Results:

  • Enabled NMR pulse synthesis and signal reception directly at Larmor frequencies up to ~2.7 GHz, improving signal-to-noise ratio (SNR) by eliminating heterodyning.
  • Implemented on-board, phase-sensitive detection using numerically controlled oscillators (NCO).
  • Facilitated windowed acquisition over extended periods and millions of pulses for nuclear spin dynamics interrogation.

Conclusions:

  • The novel NMR spectrometer architecture offers advanced capabilities for NMR pulse control and DNP.
  • The system supports closed-loop feedback control, electron decoupling, and 3D spin tracking.
  • Potential applications in quantum sensing and advanced materials analysis are highlighted.