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Updated: Sep 10, 2025

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
Ag(I)-Catalyzed Heterocyclization/[3 + 2] Cycloaddition of α-Alkynylenones with β-Enaminones: Tandem Access to Highly
Vijay Vara1,2, Kishor R Thete1,2, Sera Deepu Panikar1
1Division of Organic Chemistry, CSIR-National Chemical Laboratory, Pune 411008, India.
Abstract:
A robust Ag(I)-catalyzed tandem heterocyclization/[3 + 2] cycloaddition of α-alkynylenones with β-enaminones was developed, enabling efficient synthesis of cyclopenta[c]furans with good yields, operational simplicity, and broad substrate scope. In addition, it also presents an extended methodology to synthesize unsymmetrical tri(hetero)aryl methane having chromone and furan/pyrrole scaffolds by a slight modification of starting materials. Moreover, the synthesized cyclopenta[c]furans exhibit good fluorescence properties with quantum yields ranging from 0.33 to 0.53, as suggested by the photophysical studies.
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