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Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Hypertension I: Introduction01:28

Hypertension I: Introduction

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Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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Blood Pressure01:30

Blood Pressure

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Blood pressure (BP) is the pressure or force of blood exerted on the artery's walls as it circulates through the body. It is essential for maintaining blood flow throughout the body.
The average BP in an adult is typically around 120/80 mmHg (millimeters of mercury). In this measurement, the numerator (120) indicates the systolic pressure, which is the pressure in the arteries during the contraction of the heart's ventricles as blood is expelled. The denominator (80) represents the...
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Hypertension and Regulation of Blood Pressure01:18

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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Related Experiment Video

Updated: Sep 10, 2025

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HTSNPedia: A Molecular Perspective and Risk Estimator Database for Hypertension-Associated Genes.

Jeyanthi Sankar1, Agnal Arumugam2, A Antony Prakash2

  • 1Pharmacogenomics and CADD Lab, Department of Bioinformatics, Alagappa University, Karaikudi, Tamil Nadu, 630 003, India.

Biochemical Genetics
|August 25, 2025
PubMed
Summary

Hypertension, a global health issue, involves complex genetic and epigenetic factors. A new database, HTSNPedia, integrates data on hypertension-associated SNPs, pathways, and risk factors to aid drug discovery.

Keywords:
Blood pressure calculatorHTN risk estimatorHypertensionSNPs databasensSNPs

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Area of Science:

  • Genetics and Epigenetics
  • Cardiovascular Disease Research
  • Bioinformatics

Background:

  • Hypertension affects over a billion adults globally, driven by genetic and epigenetic factors.
  • Key signaling pathways like RAAS, KKS, and the endothelin system are implicated in hypertension development.
  • Understanding these complex interactions is crucial for effective hypertension management.

Purpose of the Study:

  • To develop a comprehensive knowledge base for hypertension research.
  • To integrate information on SNPs, biological pathways, risk factors, and pharmacogenomics.
  • To facilitate the identification of novel drug candidates for hypertension treatment.

Main Methods:

  • Developed the HTSNPedia database using HTML and Java.
  • Integrated data on Single Nucleotide Polymorphisms (SNPs) associated with hypertension.
  • Included information on relevant biological pathways, risk assessment, molecular mechanisms, and pharmacogenomics.

Main Results:

  • Created an openly accessible database, HTSNPedia.
  • The database facilitates the integration of diverse hypertension-related information.
  • Expected to improve the efficiency of identifying new pharmacological targets.

Conclusions:

  • HTSNPedia enhances the integration of hypertension-related data.
  • A deeper understanding of hypertension's molecular basis can advance human health.
  • The database supports research into novel hypertension therapies and personalized medicine.