Related Experiment Video
Updated: Sep 10, 2025

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Silver-mediated intermolecular ortho-trifluoromethoxylation of pyridyl-arenes
Lu Guo1, Ruijian Fang1, Yun Liu1
1State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry Nankai University, Tianjin 300071, China. ptang@nankai.edu.cn.
Abstract:
The direct introduction of a trifluoromethoxy group into aromatic C-H bonds is a highly desirable yet formidable transformation, primarily due to the challenges in controlling regioselectivity. While the intramolecular version of this transformation has been reported, developing an intermolecular variant has remained elusive. We herein describe a directing-group-assisted approach that enables regioselective intermolecular aromatic C-H trifluoromethoxylation. This method offers a direct approach to access aromatic trifluoromethoxy compounds.
More Related Videos
Related Concept Videos
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Preparation and Reactions of Sulfides
Nucleophilic Aromatic Substitution of Aryldiazonium Salts: Aromatic SN1
In the Sandmeyer reaction, for example, the diazonio group is replaced by a chloro, bromo,...
Hydroboration-Oxidation of Alkenes
![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
