The Importance of PET Quantification for Prognosis and Treatment Response Monitoring

PET has become an indispensable tool in medical imaging, providing critical insight into disease prognosis and treatment response. This review article aims to examine the multifaceted role of PET quantification by (1) providing an overview of the routinely used quantitative metrics and their limitations; (2) reporting how these metrics are being tested in clinical research to improve prognosis, highlighting both their potential benefits and the most promising applications; (3) defining current therapeutic assessment criteria in hemato-oncology with adaptations to innovative treatments and novel tracers; and (4) exploring advanced quantification techniques to harness large-scale data for more accurate prognostic modeling.