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Updated: Sep 10, 2025

High-throughput Screening for Protein-based Inheritance in S. cerevisiae
Published on: August 8, 2017
Faithful inheritance: Parental histone recycling and epigenetic memory in fission yeast
Yimeng Fang1,2,3,4, Takenori Toda1, Songtao Jia1
1Department of Biological Sciences, Columbia University, New York, NY, 10027, USA.
Abstract:
Accurate transmission of chromatin states during DNA replication is central to epigenetic inheritance. Recent advances have illuminated mechanisms by which parental histones, which carry key post-translational modifications, are recycled and redistributed to daughter strands. This review synthesizes emerging insights into the molecular machinery that mediates histone recycling during replication. It highlights the interplay between histone chaperones and replication factors and examines how perturbations in these pathways influence heterochromatin inheritance. The fission yeast serves as a powerful model for recent investigations, revealing new principles that are conserved across eukaryotes.
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