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Updated: Apr 16, 2026

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Published on: April 5, 2018
At the fork: where epigenetic decisions are made
1Department of Biological Sciences, Columbia University, New York, NY 10027, USA.
Abstract:
Epigenetic inheritance ensures the transmission of chromatin states through cell division, despite the dilution of parental histones during DNA replication. Recent studies reveal that inheritance is not a passive process but instead involves regulated, replication-coupled decisions coordinated by the replisome, histone chaperones, and histone modification feedback loops. In this review, I synthesize recent advances in histone recycling and chromatin inheritance, highlighting how regulated parental histone segregation underpins robust epigenetic memory. I propose a conceptual framework that positions the replication fork as an epigenetic decision-making hub and highlight key unresolved questions that will shape future studies.
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