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Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
IgE in Allergic Diseases
Dana Greene1, Jamie Moore Fried1, Julie Wang1
1Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Abstract:
Immunoglobulin E (IgE) is key in the pathogenesis of allergic diseases, exerting both systemic and local effects through high-affinity binding to FcεRI on mast cells and basophils. Cross-linking of antigen-specific IgE leads to rapid degranulation and release of histamine, leukotrienes, and other mediators, resulting in classic allergic sequelae. IgE plays a key role in conditions including food allergy, atopic dermatitis, asthma, chronic spontaneous urticaria, and chronic rhinosinusitis. Clinical applications of anti-IgE targeted therapies have demonstrated effectiveness in improving outcomes in food allergy desensitization, reducing asthma exacerbations, and treating chronic urticaria. This review highlights the critical role of IgE as a therapeutic and diagnostic target in the management of allergic disease.
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