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Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
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Titanium Implants Functionalized with Zoledronic Acid Associated with Ruterpy Accelerate Peri-Implant Repair in

Laura Vidoto Paludetto1, Isadora Breseghello1, Sabrina Cruz Tfaile Frasnelli1

  • 1Department of Basic Sciences, Araçatuba Dental School, São Paulo State University Júlio de Mesquita Filho-UNESP, Aracatuba 16015-050, SP, Brazil.

Biomimetics (Basel, Switzerland)
|August 27, 2025
PubMed
Summary

Zoledronic acid (ZOL) combined with ruterpy (TERPY) significantly accelerates peri-implant bone healing in rats, even in osteoporotic models. This combination therapy enhances bone formation and organization for improved implant stability.

Keywords:
X-ray computedbone regenerationconfocal microscopydental implantsosseointegrationosteoporosisovariectomyratssurface propertiestomographywistarzoledronic acid

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Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Regenerative Medicine

Background:

  • Osteoporosis negatively impacts bone quality, compromising dental and orthopedic implant osseointegration.
  • An optimal bone bed is critical for achieving stable and successful dental and orthopedic implants.

Purpose of the Study:

  • To investigate the efficacy of implant surface functionalization with zoledronic acid (ZOL) and ruterpy (TERPY) on peri-implant bone healing.
  • To evaluate the synergistic effects of ZOL (antiresorptive) and TERPY (osteoinductive) in both healthy and osteoporotic animal models.

Main Methods:

  • Utilized sixty-six female Wistar rats, divided into healthy (SHAM) and osteoporotic (OVX) groups.
  • Implant surfaces were either conventional (CONV), functionalized with ZOL, or co-functionalized with ZOL + TERPY.
  • Histological analysis via confocal microscopy and micro-computed tomography (Micro-CT) assessed bone healing parameters.

Main Results:

  • The ZOL + TERPY group exhibited significantly accelerated peri-implant bone repair compared to CONV and ZOL-alone groups.
  • Enhanced bone formation, organization, and improved bone volume/total volume (BV/TV), trabecular number (Tb.N), and inter-screw distance (I.S.) were observed.
  • Reduced trabecular separation (Tb.Sp) and total porosity (Po.Tot) indicated superior bone quality in the ZOL + TERPY group.

Conclusions:

  • Zoledronic acid (ZOL) combined with ruterpy (TERPY) demonstrates a synergistic effect, enhancing and accelerating bone healing around implants.
  • This combined therapy proves effective even in compromised bone states, such as osteoporosis (OVX).
  • The findings suggest ZOL + TERPY as a promising strategy for improving implant osseointegration in challenging clinical scenarios.