Related Experiment Video
Updated: Sep 10, 2025
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
Adverse Childhood Experiences and Sarcopenia in Later Life: Baseline Data from the Canadian Longitudinal Study on
Menelaos M Dimitriadis1, Kitty J E Kokkeler2, Emiel O Hoogendijk3
1Department of Psychiatry, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands.
Backgrounds:
Adverse Childhood Experiences (ACEs) are linked to early and long-lasting mental health issues and somatic multimorbidity. Emerging evidence suggests ACEs may also accelerate physical frailty in old age. This study examines the association between ACEs and sarcopenia, an ageing-related disease and core component of frailty.
Methods:
Baseline data from the Canadian Longitudinal Study on Aging (CLSA), including 25,327 participants aged 45-85 years (50.3% female sex) were analyzed. Sarcopenia was defined using the revised European Working Group of Sarcopenia in Older People (EWGSOP2) guidelines. ACE were assessed via the Childhood Experiences of Violence Questionnaire and the National Longitudinal Study of Adolescent to Adult Health Wave III questionnaire, covering eight ACE categories. Multiple logistic regression models examined the association between the number of ACE count and sarcopenia, which were adjusted for age, sex, education, income, and ethnicity.
Results:
Given a significant interaction between age and ACE (p < 0.01), analyses were stratified into four age groups (45-54, 55-64, 65-74, and 75-85 years). A significant association only emerged in the oldest group (75-85 years; OR = 0.93 [95% CI: 0.86-1.00], p = 0.043), but this result was in the opposite direction we hypothesized. Sensitivity analyses confirmed findings across different operationalisations of ACE and sarcopenia.
Conclusions:
Higher ACE exposure was not associated with sarcopenia in middle aged and older adults. The unexpected protective association in the oldest-old subgroup may reflect survival bias. Age-stratified longitudinal studies are needed to clarify this relationship.
Related Concept Videos
01:29Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
01:19The Effect of Aging on Tissues
02:20Longitudinal Research
01:09Changes in the Appendicular Skeleton with Age
Initially, the limb buds consist of a core of mesenchyme covered by a layer of ectoderm. The ectoderm at the end of the limb bud thickens to form a narrow crest called the apical ectodermal ridge. This ridge stimulates the underlying...
01:26Aging
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
01:30Cognitive Development During Adulthood