Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Modified-Release Drug Delivery Systems: Site-Targeted

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A receptor-like mechanosensitive protein governs preprophase band positioning for asymmetric cell divisions and SC morphogenesis.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

From Light to Life: Molecular Mechanisms and Macroscopic Transformations in Photoresponsive Hydrogels.

Polymer science & technology (Washington, D.C.)·2026

Same author

Dual pH- and Concentration-Dependent K<sup>+</sup> Transporter with Auto-Regulation and Anticancer Activity.

JACS Au·2026

Same author

Vertical Root Fracture in Endodontically Treated Teeth: Risk Factors and Future Directions.

Australian endodontic journal : the journal of the Australian Society of Endodontology Inc·2026

Same author

Trivalent Gadolinium Ions Forming Injectable Hydrogels for Simultaneous In Situ Vaccination Therapy and Imaging of Soft Tissue Sarcoma.

Advanced healthcare materials·2026

Same author

Modeling pH-Dependent Protein Dynamics by Integrating Coarse-Grained Molecular Simulation and the Deep Neural Network Model.

Journal of chemical theory and computation·2026

Same journal

DNAzyme-Enhanced CRISPR/Cas12a Cascade Enables Isothermal, One-Pot RNA Diagnostics.

ACS applied materials & interfaces·2026

Same journal

Continuous π-Conjugation in β-Ketoenamine Covalent Organic Frameworks Boosts Charge Transfer for Selective Photocatalysis.

ACS applied materials & interfaces·2026

Same journal

Scalable Ionogel-Based Thermochromic Smart Windows: Enhanced Solar Regulation, Weatherability, and Processability.

ACS applied materials & interfaces·2026

Same journal

Metal-Organic Framework Monoliths Derived from Emulsion-Templated Foams for Reactive Filtration.

ACS applied materials & interfaces·2026

Same journal

Binary to Quaternary Rare-Earth Phosphates: Compositional Effects on Thermal Properties and CMAS Corrosion Resistance of Environmental Barrier Coatings.

ACS applied materials & interfaces·2026

Same journal

Suture-Free Piezoelectric Band-Aid Membrane for Complex Peripheral Nerve Defects.

ACS applied materials & interfaces·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 5, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Designing Protein-Based Nanoparticles for Therapeutic Applications.

Jian Cui¹, Keqing Wang², Zheyu Wu¹

¹Collaborative Innovation Center of Advanced Microstructures, National Laboratory of Solid State Microstructure, Department of Physics, Nanjing University, Nanjing 210093, China.

ACS Applied Materials & Interfaces

|August 27, 2025

Summary

This summary is machine-generated.

Protein-based nanoparticles (PNPs) offer biocompatible drug delivery. This review details PNP design, challenges, and applications in medicine, guiding future development for personalized healthcare.

Keywords:

clinical translation design strategy nanocarrier protein-based nanoparticles therapeutic delivery

More Related Videos

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

Related Experiment Videos

Last Updated: May 5, 2026

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Manufacture and Drug Delivery Applications of Silk Nanoparticles

Published on: October 8, 2016

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Preparation of Neutrally-charged, pH-responsive Polymeric Nanoparticles for Cytosolic siRNA Delivery

Published on: May 2, 2019

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Formulating and Characterizing Lipid Nanoparticles for Gene Delivery using a Microfluidic Mixing Platform

Published on: February 25, 2021

Area of Science:

Biomaterials Science
Nanotechnology
Drug Delivery

Background:

Protein-based nanoparticles (PNPs) are versatile nanocarriers with inherent biocompatibility and biodegradability.
Their adaptable structure allows precise control over drug loading, release, and targeting for therapeutic and diagnostic uses.

Purpose of the Study:

To provide a comprehensive understanding of protein-based nanoparticle design and clinical translation.
To analyze recent studies and FDA-approved protein formulations to identify challenges and strategies.

Main Methods:

In-depth analysis of recent scientific literature on protein nanoparticles.
Review of FDA-approved protein-related formulations from the past five years.
Examination of design strategies, clinical challenges, and emerging technologies.

Main Results:

PNPs show potential in treating neurological disorders, cancer, and infectious diseases, and in diagnostics.
Key challenges include stability, immunogenicity, and manufacturing scalability.
Design strategies like surface modification, ligand targeting, and stimuli-responsive engineering can overcome barriers.

Conclusions:

Rational design of next-generation PNPs is crucial for effective, personalized healthcare solutions.
Emerging in vivo gene and protein editing technologies may accelerate PNP development and clinical translation.