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Updated: Sep 10, 2025

Induction of Intestinal Inflammation by Adoptive Transfer of CBir1 TCR Transgenic CD4+ T Cells to Immunodeficient Mice
Published on: December 16, 2021
Gut microbiota-specific T cell subset drives CNS inflammation
1Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China; Institute of Immunology, College of Life Sciences, Nankai University, Tianjin 300071, China.
None:
Gut dysbiosis and intestinal inflammation may contribute to neurological disorders through the gut-brain axis. A recent report by White et al. uncovered that intestinal inflammation triggers the migration of microbiota-specific CD4+ T cells to the brain, where they drive neuroinflammatory responses via IL-23R/GM-CSF.
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