Prognostic Value of Preoperative Hemoglobin in Patients Undergoing Radical Prostatectomy for Localized Prostate...

Area of Science:

• Urology
• Oncology
• Hematology

Background:

• Hemoglobin (Hb) is a known prognostic marker in various cancers.
• The prognostic significance of preoperative Hb levels in localized prostate cancer undergoing radical prostatectomy (RP) is not well-established.

Purpose of the Study:

• To investigate the association between preoperative hemoglobin levels and oncological outcomes in patients with localized prostate cancer treated with radical prostatectomy.

Main Methods:

• Retrospective analysis of 567 patients undergoing RP (2016-2022).
• Hb levels analyzed as continuous and binary (high vs. low) variables.
• Correlation, logistic regression, and Cox regression analyses used to assess associations with clinicopathological factors and survival outcomes (RFS, TFS, MFS).

Main Results:

• Higher Hb levels inversely correlated with patient age and International Society of Urological Pathology (ISUP) grade.
• High-Hb group showed a decreased risk of extraprostatic disease (≥pT3).
• Univariate analysis indicated longer RFS for high-Hb patients, but this was not significant after multivariate adjustment. Hb did not predict treatment-free survival (TFS) or metastasis-free survival (MFS).

Conclusions:

• Lower preoperative Hb levels are associated with more aggressive tumor grading and shorter recurrence-free survival in localized prostate cancer.
• Hemoglobin is not an independent predictor of oncological survival outcomes following radical prostatectomy in this cohort.