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The Interplay Between Oxidant/Antioxidant System, Transcription Factors, and Non-Coding RNA in Lung Cancer
Caterina Di Sano1, Claudia D'Anna1, Angela Marina Montalbano1
1Institute of Translational Pharmacology-National Research Council of Italy (IFT-CNR), 90146 Palermo, Italy.
International Journal of Molecular Sciences
|August 28, 2025
Summary
Oxidative stress from environmental factors drives lung cancer. Understanding the balance of antioxidants, cell signaling, and non-coding RNAs is key to developing new anti-cancer therapies.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- Exposure to environmental risk factors like cigarette smoke and air pollution induces cellular damage, promoting lung cancer development.
- Oxidative stress, an imbalance between pro-oxidant and antioxidant species, is critical in the pathogenesis of various diseases, including lung cancer.
- Cell signaling pathways and non-coding RNAs are integral to carcinogenesis and therapeutic resistance in lung cancer.
Purpose of the Study:
- To provide a comprehensive review of the interplay between oxidative stress, transcription factors, and non-coding RNAs in lung cancer.
- To enhance understanding of cellular interactions within this complex system for researchers and clinicians.
- To disseminate knowledge on mechanisms driving cancer development and inform new anti-cancer therapeutic strategies.
Main Methods:
- Literature review synthesizing current research on oxidative stress mechanisms in lung cancer.
- Analysis of the roles of transcription factors and non-coding RNAs in carcinogenesis.
- Exploration of the connections between oxidant/antioxidant systems and cellular signaling pathways.
Main Results:
- The balance of oxidant and antioxidant species is crucial for cellular function; its disruption contributes to lung cancer onset and progression.
- Cell signaling and non-coding RNAs are involved in lung cancer development and resistance to therapy.
- The interplay between oxidative stress, transcription factors, and non-coding RNAs is fundamental to lung cancer pathogenesis.
Conclusions:
- A deeper understanding of the oxidative stress-transcription factor-non-coding RNA axis can improve lung cancer treatment efficacy.
- Targeting these mechanisms offers new pharmacological strategies for controlling inflammation and disease progression.
- This knowledge is vital for advancing therapeutic interventions and improving patient outcomes in lung cancer.
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