Age-Related Characteristics of Diastolic Dysfunction in Type 2 Diabetes Patients
Elena-Daniela Grigorescu1,2, Bogdan-Mircea Mihai1,2, Georgiana-Diana Cazac-Panaite1,2
1Unit of Diabetes, Nutrition, and Metabolic Diseases, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 700115 Iasi, Romania.
Journal of Clinical Medicine
|August 28, 2025
Summary
Asymptomatic left ventricular diastolic dysfunction (LVDD) is common in type 2 diabetes mellitus (T2DM) patients. Age over 65 is a significant predictor of LVDD, necessitating early echocardiographic screening in elderly T2DM individuals.
Area of Science:
- Cardiology
- Endocrinology
- Diabetology
Background:
- Asymptomatic left ventricular diastolic dysfunction (LVDD) is prevalent in type 2 diabetes mellitus (T2DM) patients, particularly the elderly.
- This study focuses on T2DM patients without established atherosclerotic cardiovascular disease.
Purpose of the Study:
- To track changes in diastolic function over 52 weeks in T2DM patients.
- To identify predictors of LVDD in T2DM patients without atherosclerotic manifestations.
- To analyze diastolic function across different age groups.
Main Methods:
- Echocardiographic assessment of diastolic function.
- Measurement of metabolic profile, atherogenic indexes, and inflammatory markers.
- Longitudinal follow-up over 52 weeks in 138 T2DM outpatients.
Main Results:
- Age over 65 was an independent risk factor for LVDD (Exp B = 9.85, p = 0.027).
- LVDD patients exhibited longer diabetes duration and higher rates of diabetic neuropathy.
- Elderly patients showed distinct echocardiographic and inflammatory profiles, with worsened diastolic function in 27 individuals over 52 weeks.
Conclusions:
- LVDD is frequent in T2DM patients without known cardiovascular disease.
- Advanced age is a key risk factor for developing LVDD in T2DM.
- Echocardiography is crucial for early detection and risk stratification of heart failure progression in elderly T2DM patients.
Keywords:
elderlyinflammatory markersleft ventricular diastolic dysfunction (LVDD)type 2 diabetes mellitus (T2DM)More Related Videos
11:00Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
Published on: September 18, 2017
10.2K
04:48Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery
Published on: November 28, 2018
8.0K
Related Concept Videos
01:29Heart Failure II: Pathophysiology
37
Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
37
01:30Cardiomyopathy II: Dilated Cardiomyopathy
21
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
21
01:15Diabetes: Symptoms, Diagnosis, and Complications
685
For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
685
01:22Diabetes Mellitus: Type 2 and Gestational
2.9K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.9K
01:29Cardiomyopathy IV: Restrictive Cardiomyopathy
27
Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
27
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
45
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
45