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Transthoracic Speckle Tracking Echocardiography for the Quantitative Assessment of Left Ventricular Myocardial Deformation
Published on: October 20, 2016
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Aortic Valve Annular Characteristics in Isolated Left Ventricular Non-Compaction-Detailed Analysis from the
Attila Nemes1, Nóra Ambrus1, Máté Vámos1
1Department of Medicine, Albert Szent-Györgyi Medical School, University of Szeged, H-6725 Szeged, Hungary.
Journal of Clinical Medicine
|August 28, 2025
Summary
Left ventricular non-compaction (LVNC) patients frequently show a larger end-diastolic aortic valve annulus area. This condition is associated with reduced aortic valve annular plane systolic excursion and impaired left ventricular strain, regardless of annulus area changes.
Area of Science:
- Cardiology
- Echocardiography
- Cardiac Imaging
Background:
- Left ventricular non-compaction (LVNC) is a rare cardiomyopathy characterized by a thickened, non-compacted endocardial layer.
- Existing literature lacks data on aortic valve annulus (AVA) abnormalities in LVNC.
- This study investigates AVA characteristics in LVNC using advanced echocardiography.
Purpose of the Study:
- To analyze the aortic valve annulus (AVA) in patients with isolated left ventricular non-compaction (LVNC).
- To compare AVA dimensions and function in LVNC patients versus healthy controls using 3D speckle-tracking echocardiography (3DSTE).
- To assess the relationship between AVA morphology and left ventricular (LV) myocardial strain in LVNC.
Main Methods:
- 12 isolated LVNC patients and 38 matched healthy controls underwent 3D speckle-tracking echocardiography (3DSTE).
- Detailed analysis of aortic valve annulus (AVA) dimensions and aortic valve annular plane systolic excursion (AAPSE) was performed.
- Subgroup analysis compared patients with greater end-diastolic versus end-systolic AVA area.
Main Results:
- While most AVA dimensions were similar, LVNC patients more frequently exhibited a larger end-diastolic AVA area (75% vs 29%, p < 0.05).
- Aortic valve annular plane systolic excursion (AAPSE) was significantly reduced in LVNC patients (p < 0.05).
- Reduced basal left ventricular radial, longitudinal, and circumferential strain were observed in LVNC patients, irrespective of AVA area configuration.
Conclusions:
- Isolated LVNC is not typically associated with aortic valve annulus dilation.
- A larger end-diastolic AVA area is more prevalent in LVNC patients compared to controls.
- Reduced AAPSE and impaired LV myocardial strain are characteristic findings in LVNC, highlighting potential valvulo-ventricular interaction.
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