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Electrospinning Growth Factor Releasing Microspheres into Fibrous Scaffolds

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Published on: August 16, 2014

Electrospun PEDOT-Based Meshes for Skin Regeneration.

Alexandra I F Alves¹, Nuno M Alves¹, Juliana R Dias¹

¹CDRSP-IPLeiria-Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, 2430-028 Marinha Grande, Portugal.

|August 28, 2025

Summary

Conductive polymer wound dressings made from chitosan, gelatin, and poly(3,4-ethylenedioxythiophene) (PEDOT) were created using electrospinning. These novel materials show promise for enhancing skin tissue regeneration and wound healing through electrical stimulation.

Keywords:

PEDOT conductive electrospun fibers in situ chemical polymerization skin regeneration wound dressing

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Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Combination of Microstereolithography and Electrospinning to Produce Membranes Equipped with Niches for Corneal Regeneration

Published on: September 12, 2014

Area of Science:

Biomaterials Science
Tissue Engineering
Polymer Chemistry

Background:

Conductive polymers offer potential for wound healing by delivering electrical stimuli to promote cell growth.
Electrospinning is a versatile technique for creating skin-like scaffolds that manage wound environments.

Purpose of the Study:

To synthesize and characterize conductive, biodegradable chitosan/gelatin/poly(3,4-ethylenedioxythiophene) electrospun meshes.
To evaluate the potential of these meshes as electrostimulated wound dressings for skin tissue engineering.

Main Methods:

In situ chemical polymerization of poly(3,4-ethylenedioxythiophene) (PEDOT) with hyaluronic acid-doping.
Production of chitosan (CS)/gelatin (GEL)/PEDOT electrospun meshes via electrospinning.
Crosslinking of meshes with 1,4-butanediol diglycidyl ether and investigation of physicochemical and mechanical properties.

Main Results:

Incorporation of PEDOT increased solution conductivity, density, and fiber diameter, affecting mesh porosity, water uptake, and biodegradability.
Maintained appropriate water vapor permeation values.
CS/GEL/PEDOT meshes exhibited properties suitable for electrostimulated wound dressings.

Conclusions:

The developed CS/GEL/PEDOT electrospun nanofibrous meshes show significant potential for electrostimulated wound dressings.
Their structural similarity to the extracellular matrix and cell-binding properties support skin tissue engineering applications.