Multifunctional Responsive Gas-Releasing Metal Organic Framework Nanoplatform for Tumor Therapy Application.

Area of Science:

• Nanotechnology
• Materials Science
• Biomedical Engineering

Background:

• Gas therapy (GT) shows promise for regulating the tumor microenvironment using therapeutic gases.
• Conventional gas-releasing molecules (GRMs) face challenges in controllability, targeting, and stability.

Purpose of the Study:

• To review the preparation and modulation of metal-organic frameworks (MOFs) for enhanced gas therapy.
• To highlight the advantages of MOF-based nanoplatforms for efficient loading and responsive release of therapeutic gases in tumor treatment.

Main Methods:

• Focus on the preparation and modulation of MOFs.
• Systematic description of MOF-based GRM nanoplatforms.
• Review of recent progress in MOF-based GT for tumor treatment.

Main Results:

• MOFs offer high surface area, tunable porosity, and active sites for enhanced gas storage and release.
• MOF-based nanoplatforms demonstrate efficient loading and targeted, responsive release of gases (O2, NO, H2).
• MOFs improve the stability and controllability of gas release for GT.

Conclusions:

• MOF-based nanoplatforms represent an innovative solution to overcome limitations of conventional GRMs in GT.
• These platforms offer more effective and safer therapeutic strategies for clinical tumor treatment.
• Further research into challenges and future perspectives of MOF-based GT is warranted.