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Peripheral Blood-based NRN1 and TNFAIP3 Gene Expression as Minimally Invasive Biomarkers for Gastric Cancer
Daniel Soares Queiroz1, Yeda Beatriz Louredo Santos1, Leonardo Caires Santos2
1Discipline of Gastroenterology, Department of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Background/Aim:
Gastric cancer (GC) remains one of the most common and fatal cancer types worldwide. Herein, we explored neuritin 1 (NRN1) and tumor necrosis factor alpha-induced protein 3 (TNFAIP3) as minimally invasive biomarkers of GC.
Materials And Methods:
The NRN1 and TNFAIP3 mRNA levels in the peripheral blood samples of 42 patients with GC were compared with 12 individuals with no cancer diagnosis, and monitored after gastrectomy.
Results:
NRN1 expression was elevated in patients compared with controls (p<0.01), and was able to discriminate between these groups (area under the curve=0.72, p=0.02). After resection of the primary tumor, NRN1 expression decreased (p<0.01), reaching levels observed in controls. TNFAIP3 expression showed no difference between patients and controls, nor postoperatively.
Conclusion:
Peripheral blood-based NRN1 expression can be used as a minimally invasive biomarker for GC detection and postoperative monitoring.
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