A modular, nanoscale platform for the targeted delivery of camptothecin to cancer cells expressing TAG-72
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Reham Hassan1, Zirui Zhu1, Mingyang Ji1
1Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, Ohio 43210, USA. parquette.1@osu.edu.
Biomaterials Science
|August 29, 2025
Abstract:
A camptothecin (CPT)-dilysine nanotube, stabilized with a layer of polydopamine (PDA), was functionalized on the surface with anti-TAG-72 antibody fragments. Cell viability studies showed that the presence of the targeting anti-TAG-72 scFv significantly enhanced cytotoxicity against TAG-72 positive, LS-174T colon cancer cells, compared with HT-29 cells negative for the antigen.
