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Related Concept Videos

Fractures: Bone Repair01:27

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Treatment for a fracture is based on the type of break, the bone affected, and the patient's age.
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Related Experiment Video

Updated: Sep 9, 2025

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Preliminary Data From a Geriatrician-Led Program for Orthopedic Co-Managed Hip Fracture Patients Using Zoledronic

Karen Chahal1, Jessica Nguyen2, Diviya Rajesh3

  • 1Beth Israel Deaconess Medical Center, Department of Medicine, Division of Gerontology & Harvard Medical School, Boston, Massachusetts, USA.

Journal of the American Geriatrics Society
|August 29, 2025
PubMed
Summary

An inpatient osteoporosis treatment program using Zoledronic Acid (ZA) effectively managed hip fracture patients, with 39.2% receiving treatment before discharge. This approach is feasible for improving care in older adults with hip fractures.

Keywords:
co‐managed carehip fractureinpatientosteoporosiszoledronic acid

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Area of Science:

  • Geriatric Medicine
  • Orthopedic Surgery
  • Pharmacology

Background:

  • Hip fractures are a growing concern in the aging US population, leading to significant health issues and costs.
  • Current guidelines recommend osteoporosis treatment post-hip fracture, yet adherence remains low.
  • An academic hospital implemented an inpatient osteoporosis treatment program using Zoledronic Acid (ZA) for hip fracture patients.

Purpose of the Study:

  • To describe the implementation of an inpatient osteoporosis treatment program for hip fracture patients.
  • To evaluate the preliminary data on the program's effectiveness and feasibility.

Main Methods:

  • A prospective cohort study included patients aged 65+ with surgically repaired hip fractures.
  • The Zoledronic Acid (ZA) program involved geriatricians, nursing, and pharmacy, screening patients for eligibility (creatinine clearance >/= 35 mL/min, Vitamin D >/= 20 ng/mL).
  • The RE-AIM framework assessed program reach, effectiveness, adoption, and implementation.

Main Results:

  • Over 20 months, 232 hip fracture patients were admitted; 148 were screened, and 67 (45.3%) were eligible for ZA.
  • 58 patients (39.2%) received ZA before discharge; common ineligibility reasons included low Vitamin D and inadequate kidney function.
  • No adverse events or discharge delays were observed in treated patients; screening/treatment averaged 30 minutes.

Conclusions:

  • A co-managed inpatient Zoledronic Acid (ZA) program led by geriatrics is a feasible strategy for treating osteoporosis in hospitalized hip fracture patients.
  • The program demonstrates potential for improving osteoporosis management in this vulnerable population.