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![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Photoredox/Nickel Dual Catalysis for Regio- and Stereoselective Reductive Coupling of Alkynes with Vinyl Phosphonates
Radhakrishnan Sakthiganapathi1, Dhanip Kumar Sharma1, Rituparna Dutta1
1Department of Chemistry, SRM University-AP, Amaravati, Andhra Pradesh 522240, India.
Abstract:
An efficient nickel-photoredox dual-catalyzed intermolecular reductive coupling reaction of alkynes with vinyl phosphonates is described. The reaction is highly regio- and stereoselective, affording the homoallylic phosphonates in good to high yields. The present protocol is also successfully applied to other activated alkenes such as enones, acrylates, and vinyl sulfone. The reaction is believed to proceed via the nickelacyclopentene intermediate. Mechanistic investigations, including control experiments and isotopic labeling studies, revealed that methanol serves as a proton source rather than a reducing agent.
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