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Updated: Sep 9, 2025

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis

Catheter-based Endovascular Angioplasty for Fibrosing Mediastinitis-associated Pulmonary Vein Stenosis

Published on: August 26, 2025

Left Atrial Papillary Fibroelastoma and Mediastinal Radiotherapy.

Wei Jun How¹, Trishla Patel¹, Nadim Malik²

¹Manchester Heart Centre, Manchester University NHS Foundation Trust, Manchester, United Kingdom.

JACC. Case Reports

|August 29, 2025

Summary

This summary is machine-generated.

Mediastinal radiotherapy can cause long-term cardiac issues, including mitral valve degeneration and rare tumors like papillary fibroelastomas (PFEs). Early detection and surgical intervention are crucial for managing these potentially serious complications in cancer survivors.

Keywords:

cancer echocardiography mitral valve three-dimensional imaging

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Robotic Ablation of Atrial Fibrillation

Robotic Ablation of Atrial Fibrillation

Published on: May 29, 2015

Area of Science:

Cardiology
Oncology
Radiotherapy

Background:

High-dose mediastinal radiotherapy is linked to progressive valvular degeneration and secondary malignancy.
Cancer survivors treated with chest radiotherapy face risks of long-term cardiac complications.

Observation:

A 50-year-old woman with a history of Hodgkin lymphoma treated with chest radiotherapy and stem cell transplantation presented with dyspnea.
Echocardiography revealed severe mitral regurgitation, mitral annular calcification, and an incidental left atrial mass.

Findings:

The patient underwent mitral valve replacement and mass resection.
Histology confirmed a fibrotic mitral valve and a papillary fibroelastoma (PFE).

Implications:

Radiation-induced fibrosis may contribute to mitral valve degeneration and PFE development.
Papillary fibroelastomas, though benign, pose an embolic risk requiring surgical management.
Cardiac complications, including rare tumors, can emerge decades after mediastinal radiotherapy.