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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
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Image-Guided Adaptive Cryotherapy for Prostate Cancer Treatment.

Eva Beek1,2, Nobuhiko Hata3, Kemal Tuncali4

  • 1Department of Radiology, Brigham & Women's Hospital, Harvard Medical School, 75 Francis St., Boston, 02115, MA, USA. e.x.beek@student.tue.nl.

Annals of Biomedical Engineering
|August 29, 2025
PubMed
Summary
This summary is machine-generated.

Image-guided Adaptive Cryotherapy (ImAC) optimizes prostate cancer treatment by improving needle placement accuracy. This novel approach may reduce the experience needed for effective focal cryoablation.

Keywords:
3D SlicerAdaptive needle placementFocal cryoablationMRI-guided cryoablationProstate cancer

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Area of Science:

  • Urology
  • Medical Imaging
  • Oncology

Background:

  • Focal cryoablation is a prostate cancer treatment with reduced side effects.
  • Physician experience is crucial for managing needle deflection during cryoablation.

Purpose of the Study:

  • To develop and evaluate Image-guided Adaptive Cryotherapy (ImAC) for MRI-guided prostate cryoablation.
  • To determine if ImAC can optimize needle placement and reduce physician experience requirements.

Main Methods:

  • ImAC was designed to calculate optimal needle placement considering needle deflection and iceball formation.
  • The system's performance was evaluated through simulations of 21 needle insertions.

Main Results:

  • ImAC achieved a greater median minimum ablation margin (5.0 mm) compared to an experienced physician (3.4 mm).
  • Needle placement adjustments were similar between ImAC and the physician (± 7.5 mm).

Conclusions:

  • ImAC demonstrates potential for optimizing needle placement in prostate cryoablation.
  • This adaptive strategy may decrease the learning curve for effective cryoablation procedures.