CONCEPTUAL AND THEORETICAL EXPLORATION OF TREATMENT OF PATIENTS WITH ONYCHOMYCOSIS

Area of Science:

• Mycology
• Dermatology
• Pharmacology

Background:

• Onychomycosis (fungal nail infection) understanding and treatment are evolving.
• New therapeutic strategies are needed to optimize patient care for fungal nail diseases.

Purpose of the Study:

• To optimize medical care for onychomycosis patients.
• To evaluate the efficacy of therapeutic agents that improve nail plate structure and growth.

Main Methods:

• A study involving 147 patients (aged 23-79) with various onychomycosis forms.
• Main group received systemic antifungal drug plus a biotin-containing agent; control group received only systemic antifungal drug.
• Evaluations included microscopic examination, cultural studies, PCR, epiluminescence microscopy, dermatoscopy, and nail damage index determination.

Main Results:

• Combined therapy showed a 1.4 times higher nail plate growth rate (0.77±0.02 cm) compared to the control group (0.53±0.03 cm).
• Mycological remission was achieved in 89.1% of the combined therapy group, 19.5% higher than the control group.
• Normal nail plate structure was restored in 96.8% of patients with combined treatment versus 81.5% in the control group.

Conclusions:

• A comprehensive approach combining antifungal agents with nail-structure-improving agents is effective for onychomycosis.
• This method leads to mycological elimination and positive clinical outcomes, including faster nail regrowth and structural restoration.
• The developed method significantly enhances treatment success rates for fungal nail infections.