Lymphoma encasing the heart: large mediastinal mass with myocardial infiltration and coronary artery involvement

Related Experiment Video

Updated: Sep 9, 2025

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

10.5K

Taraneh Aziz-Safaie1,2, Alexander M C Böhner1, Julian A Luetkens1,2

  • 1Department of Diagnostic and Interventional Radiology, University Hospital Bonn, Venusberg-Campus 1, 53127, Bonn, Germany.

The International Journal of Cardiovascular Imaging
|August 30, 2025
PubMed

Insights

Primary mediastinal B-cell lymphoma can infiltrate the heart and encase coronary arteries, causing chest pain in young patients. Advanced imaging like cardiac MRI and photon-counting CT is vital for early detection, impacting treatment and prognosis.

Area of Science:

  • Cardiovascular Medicine
  • Oncology
  • Radiology

Background:

  • Primary mediastinal B-cell lymphoma (PMBCL) is a rare malignancy.
  • Cardiac involvement, including myocardial infiltration and coronary artery encasement, presents a diagnostic challenge.
  • Symptoms like chest pain and dyspnea in young adults may indicate advanced disease.

Purpose of the Study:

  • To highlight the significance of cardiac involvement in PMBCL.
  • To emphasize the role of advanced imaging in diagnosing myocardial and coronary artery infiltration.
  • To underscore the importance of early recognition for treatment and prognosis.

Main Methods:

  • Review of clinical cases with PMBCL and cardiac involvement.
  • Analysis of diagnostic capabilities of cardiac magnetic resonance imaging (CMR).
  • Evaluation of photon-counting coronary computed tomography (CT) angiography for detecting coronary artery encasement.

Main Results:

  • PMBCL can lead to direct myocardial infiltration.
  • Coronary artery encasement by lymphoma is a critical finding.
  • CMR and photon-counting CT are effective in visualizing these cardiac abnormalities.

Conclusions:

  • Cardiac involvement in PMBCL is a critical prognostic factor.
  • Advanced imaging techniques are essential for accurate diagnosis.
  • Timely identification of cardiac infiltration influences therapeutic strategies and patient outcomes.

Keywords:
Computed tomography angiographyCoronary vesselsLymphoma, B-cellMagnetic resonance imagingMediastinal neoplasms

More Related Videos

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer03:55

Computer-Aided Three-Dimensional Visualization in the Treatment of Locally Advanced Thyroid Cancer

Published on: June 9, 2023

620
Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction05:48

Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction

Published on: August 9, 2022

4.6K

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
28
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...
27
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
45
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
20
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
32
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
50