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Assessing LLM-generated vs. expert-created clinical anatomy MCQs: a student perception-based comparative study in
Maram Elzayyat1, Janatul Naeim Mohammad1, Sami Zaqout1
1Department of Basic Medical Sciences, College of Medicine, QU Health, Qatar University, Doha, Qatar.
Medical Education Online
|August 30, 2025
Summary
Large language models (LLMs) can generate medical education multiple-choice questions (MCQs) comparable to expert-written ones. AI-generated MCQs help identify knowledge gaps, but expert review ensures quality and curriculum alignment.
Area of Science:
- Medical Education
- Artificial Intelligence in Education
- Anatomy Assessment
Background:
- Large language models (LLMs) are increasingly utilized for generating educational content in medical settings.
- The efficacy of LLM-generated multiple-choice questions (MCQs) compared to expert-authored questions in anatomy education is not well-established.
Purpose of the Study:
- To compare the quality and effectiveness of MCQs generated by ChatGPT, Google-Gemini, and a clinical anatomist.
- To evaluate learner perceptions of AI-generated versus expert-written anatomy MCQs.
Main Methods:
- A cross-sectional, mixed-methods study involving 48 medical students.
- Participants completed and evaluated three sets of anonymized MCQs (ChatGPT, Gemini, expert-authored) based on 17 quality criteria.
- Descriptive statistics, chi-square analysis, and thematic review of qualitative feedback were employed.
Main Results:
- Most students perceived MCQs from all three sources as equally effective.
- ChatGPT was frequently preferred for identifying knowledge gaps via challenging distractors.
- Expert-written questions were rated highest for promoting deeper analytical thinking; significant preference variations were noted (χ²(64) = 688.79, p < .001).
Conclusions:
- LLM-generated anatomy MCQs demonstrate comparable learner-perceived value to expert-authored questions.
- AI-generated MCQs can enhance engagement, but expert oversight is crucial for clarity and curricular alignment.
- A hybrid AI-human approach offers a scalable solution for high-quality medical education assessment design.
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